Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/89676
Title: Optimization of chemotherapy and immunotherapy: In silico analysis using pharmacokinetic-pharmacodynamic and tumor growth models
Authors: Kiran, K.L.
Lakshminarayanan, S. 
Keywords: Cancer
Chemotherapy
Immunotherapy
Mathematical model
Multi-objective optimization
Non-dominated sorting genetic algorithm
Issue Date: Mar-2013
Citation: Kiran, K.L., Lakshminarayanan, S. (2013-03). Optimization of chemotherapy and immunotherapy: In silico analysis using pharmacokinetic-pharmacodynamic and tumor growth models. Journal of Process Control 23 (3) : 396-403. ScholarBank@NUS Repository.
Abstract: Chemotherapy is one of the most prominent cancer treatment modalities. However, it is not always a comprehensive solution for tumor regression. This led to the advent of novel strategies to combine chemotherapy with other emerging therapies to treat cancer patients keeping side effects to a minimum. In this work, the focus is on the optimization of chemotherapy using doxorubicin and its combination with adoptive-cell-transfer therapy which is one of the schemes of immunotherapy. The key challenge in the combination therapy is to find the sequence, timing and the dosage of therapies for a given patient. In this regard, an in silico pharmacokinetic/pharmacodynamic model describing the interaction between tumor cells, immune cells and doxorubicin is used to formulate a multi-objective optimization problem by considering clinically relevant objectives and constraints. Then, the multi-objective optimization problem is solved using genetic algorithm and the results obtained for the different cases are compared to discover a therapeutically efficacious treatment regimen. And the metrics used to compare different cases are final tumor size and tumor relapse time. The comparison between chemotherapy alone and its combination with immunotherapy shows that combination therapy is effective in controlling the tumor growth. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Journal of Process Control
URI: http://scholarbank.nus.edu.sg/handle/10635/89676
ISSN: 09591524
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

4
checked on Mar 8, 2018

WEB OF SCIENCETM
Citations

3
checked on Apr 16, 2018

Page view(s)

41
checked on Jun 8, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.