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https://doi.org/10.1002/aic.12336
Title: | Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements | Authors: | Zhou, Z. Xiao, Y. Hatton, T.A. Chung, T.-S. |
Keywords: | Chiral separation Enantiomers Human serum albumin Membrane separation Selective permeation enhancement |
Issue Date: | May-2011 | Citation: | Zhou, Z., Xiao, Y., Hatton, T.A., Chung, T.-S. (2011-05). Novel membrane processes for the enantiomeric resolution of tryptophan by selective permeation enhancements. AIChE Journal 57 (5) : 1154-1162. ScholarBank@NUS Repository. https://doi.org/10.1002/aic.12336 | Abstract: | Novel membrane processes for the effective enantioresolution of racemic mixtures have been evaluated. The incorporation of human serum albumin (HSA) in the strip solution of a permeation cell resulted in the partial optical resolution of a racemic tryptophan mixture, as the permeation of L-tryptophan, which binds to HSA more strongly, was enhanced selectively over that of D-tryptophan. A second approach in which a racemic mixture was introduced to the strip solution prior to the experiments showed better performance by selectively decreasing the flux of the more weakly bound D-tryptophan. The highest enantioselectivity of ~9.76 was achieved with a third, novel design consisting of two permeation cells in series, which can encompass the advantages of affinity dialysis. An industrial scale unit is proposed based on this concept and a suitably validated mathematical model. Copyright © 2010 American Institute of Chemical Engineers (AIChE). | Source Title: | AIChE Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/89608 | ISSN: | 00011541 | DOI: | 10.1002/aic.12336 |
Appears in Collections: | Staff Publications |
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