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Title: Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion
Authors: Kanaujia, P.
Lau, G.
Ng, W.K.
Widjaja, E.
Hanefeld, A.
Fischbach, M.
Maio, M.
Tan, R.B.H. 
Keywords: Amorphous formulation
Dissolution rate
Melt extrusion
Solid dispersion
Solid solution
Issue Date: Jul-2011
Citation: Kanaujia, P., Lau, G., Ng, W.K., Widjaja, E., Hanefeld, A., Fischbach, M., Maio, M., Tan, R.B.H. (2011-07). Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion. Journal of Pharmaceutical Sciences 100 (7) : 2876-2885. ScholarBank@NUS Repository.
Abstract: The aim of this study is to examine the physical mechanisms during the dissolution of a solid dispersion, so as to provide further understanding behind the enhanced dissolution properties. X-ray amorphous solid dispersions of ketoconazole (KC), a poorly aqueous soluble drug, were prepared by melt extrusion with polyvinlypyrrolidone 17 (PVP 17) and PVP-vinyl acetate (PVP-VA64) copolymer. Prior to dissolution, Raman mapping showed a fully homogeneous spatial distribution of KC in polymer and possible drug dispersion at molecular level, whereas Fourier transform infrared spectroscopy revealed no drug-polymer chemical interaction. During in vitro dissolution test, a burst release followed by a gradual decline in dissolution could be explained by the release of KC in molecular form followed by formation of drug nanoparticles and their subsequent growth to micron size range as shown by dynamic light scattering analysis. Observations using transmission electron microscopy and cryogenic scanning electron microscopy provided support to the suggested mechanisms. The results suggested that the release of KC from the solid dispersions was carrier controlled initially, and PVP 17 PF is more efficient in inhibiting particle growth as compared with PVP-VA64. The particle growth inhibition during dissolution may be an important consideration to achieve the full benefits of dissolution enhancement of solid dispersions. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association.
Source Title: Journal of Pharmaceutical Sciences
ISSN: 00223549
DOI: 10.1002/jps.22491
Appears in Collections:Staff Publications

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