Please use this identifier to cite or link to this item: https://doi.org/10.2217/nnm.10.13
Title: Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment
Authors: Pan, J.
Liu, Y.
Feng, S.-S. 
Keywords: Cancer nanotechnology
Drug delivery
Molecular imaging
Nanobiotechnology
Quantum dots
Taxotere®
Issue Date: Apr-2010
Citation: Pan, J., Liu, Y., Feng, S.-S. (2010-04). Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment. Nanomedicine 5 (3) : 347-360. ScholarBank@NUS Repository. https://doi.org/10.2217/nnm.10.13
Abstract: Aims: A multifunctional nanoparticle (NP) system is developed to provide a sustained, controlled and targeted co-delivery of quantum dots (QDs) as a model imaging agent and docetaxel as a model anticancer drug. The NPs are made of a polymeric blend of poly(lactic-co-glycolic acid), which forms a biodegradable NP matrix, and the novel copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-COOH, which facilitates ligand conjugation on the NP surface. Materials & methods: The NPs were prepared by nanoprecipitation and characterized for their size and size distribution, surface morphology, surface charge, QD/drug encapsulation and loading efficiency, and in vitro drug release profile. The targeting effects of such NPs were evaluated both quantitatively and qualitatively through the cellular uptake of the QDs as well as the cytotoxicity of the drug using MCF-7 cells, which overexpress folate receptors and NIH 3T3 cells, which have no folate receptors overexpression. Results & conclusions: NPs with folate conjugated on their surface achieved much higher cellular uptake than those with no folate conjugation in MCF-7 cells while no significant targeting effect could be observed for NIH 3T3 cells. The drug formulated in the folate-conjugated NPs were more efficious compared with NPs with no folate conjugation as well as the current clinical formulation Taxotere®. © 2010 Future Medicine Ltd.
Source Title: Nanomedicine
URI: http://scholarbank.nus.edu.sg/handle/10635/89511
ISSN: 17435889
DOI: 10.2217/nnm.10.13
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

44
checked on Sep 25, 2018

WEB OF SCIENCETM
Citations

39
checked on Sep 18, 2018

Page view(s)

30
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.