Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M112.445890
Title: MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma
Authors: Van Der Deen, M.
Taipaleenmäki, H.
Zhang, Y.
Teplyuk, N.M.
Gupta, A.
Cinghu, S.
Shogren, K.
Maran, A.
Yaszemski, M.J.
Ling, L.
Cool, S.M.
Leong, D.T. 
Dierkes, C.
Zustin, J.
Salto-Tellez, M. 
Ito, Y.
Bae, S.-C.
Zielenska, M.
Squire, J.A.
Lian, J.B.
Stein, J.L.
Zambetti, G.P.
Jones, S.N.
Galindo, M.
Hesse, E.
Stein, G.S.
Van Wijnen, A.J. 
Issue Date: 19-Jul-2013
Citation: Van Der Deen, M., Taipaleenmäki, H., Zhang, Y., Teplyuk, N.M., Gupta, A., Cinghu, S., Shogren, K., Maran, A., Yaszemski, M.J., Ling, L., Cool, S.M., Leong, D.T., Dierkes, C., Zustin, J., Salto-Tellez, M., Ito, Y., Bae, S.-C., Zielenska, M., Squire, J.A., Lian, J.B., Stein, J.L., Zambetti, G.P., Jones, S.N., Galindo, M., Hesse, E., Stein, G.S., Van Wijnen, A.J. (2013-07-19). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry 288 (29) : 21307-21319. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.445890
Abstract: Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/89415
ISSN: 00219258
DOI: 10.1074/jbc.M112.445890
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