Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.compbiomed.2011.04.017
Title: Mathematical modeling and sensitivity analysis of the integrated TNFα-mediated apoptotic pathway for identifying key regulators
Authors: Koh, G.
Lee, D.-Y. 
Keywords: Mathematical modeling
Regulatory mechanisms
Sensitivity analysisApoptosis
Issue Date: Jul-2011
Citation: Koh, G., Lee, D.-Y. (2011-07). Mathematical modeling and sensitivity analysis of the integrated TNFα-mediated apoptotic pathway for identifying key regulators. Computers in Biology and Medicine 41 (7) : 512-528. ScholarBank@NUS Repository. https://doi.org/10.1016/j.compbiomed.2011.04.017
Abstract: TNFα-mediated apoptosis is one of the complex and tightly regulated cellular processes as it involves the activation of both pro- and anti-apoptotic signaling pathways. Thus, it is important to elucidate the molecular players of this process and their dynamics in order to gain an in-depth understanding of the mechanisms underlying apoptosis. To this end, we proposed an integrated model of TNFα-mediated apoptosis pathway in Type I cells, formulated based on the principles of mass action kinetics. The model includes major apoptotic modules-the extrinsic and intrinsic pathways, the NFB survival signaling and various regulatory mechanisms. We performed simulations and sensitivity analyses to study the role of NFB pathway in regulating apoptosis, and identified IAP as one of the more potent regulators of apoptosis. © 2011 Elsevier Ltd.
Source Title: Computers in Biology and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/89361
ISSN: 00104825
DOI: 10.1016/j.compbiomed.2011.04.017
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