Please use this identifier to cite or link to this item: https://doi.org/10.1002/chir.20078
Title: Kinetic resolution of ibuprofen catalyzed by Candida rugosa lipase in ionic liquids
Authors: Hongwei, Y.
Jinchuan, W.
Bun, C.C. 
Keywords: Candida rugosa
Ibuprofen
Ionic liquid
Kinetic resolution
Lipase
Issue Date: 2005
Source: Hongwei, Y., Jinchuan, W., Bun, C.C. (2005). Kinetic resolution of ibuprofen catalyzed by Candida rugosa lipase in ionic liquids. Chirality 17 (1) : 16-21. ScholarBank@NUS Repository. https://doi.org/10.1002/chir.20078
Abstract: Candida rugosa lipase-catalyzed esterification of ibuprofen with 1-propanol was conducted in seven ionic liquids and the results were compared with those in isooctane. Although the enzyme showed comparable or higher activity in some ionic liquids compared to that in isooctane, only in the case of [BMIM]PF 6 was the enantioselectivity (E = 24.1) almost twice that (E = 13.0) of isooctane. In another six ionic liquids the enzyme enantioselectivity was much poorer (E = 1.1-6.4). At the same conversion of 30%, E of [BMIM]PF 6 is more than triple that of isooctane. The lipase stability in [BMIM]PF6 was improved by 25% of that in isooctane. It was concluded that [BMIM]PF6 could be applied to substitute the conventional organic solvent (isooctane) in the esterification of ibuprofen. © 2004 Wiley-Liss, Inc.
Source Title: Chirality
URI: http://scholarbank.nus.edu.sg/handle/10635/89306
ISSN: 08990042
DOI: 10.1002/chir.20078
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

30
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

47
checked on Feb 14, 2018

Page view(s)

29
checked on Feb 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.