Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2py20264f
Title: Fluorescent nanoparticles from self-assembly of β-cyclodextrin- functionalized fluorene copolymers for organic molecule sensing and cell labeling
Authors: Xu, L.Q.
Zhang, B.
Wang, R.
Chen, Y.
Neoh, K.-G. 
Kang, E.-T. 
Fu, G.D.
Issue Date: Sep-2012
Source: Xu, L.Q., Zhang, B., Wang, R., Chen, Y., Neoh, K.-G., Kang, E.-T., Fu, G.D. (2012-09). Fluorescent nanoparticles from self-assembly of β-cyclodextrin- functionalized fluorene copolymers for organic molecule sensing and cell labeling. Polymer Chemistry 3 (9) : 2444-2450. ScholarBank@NUS Repository. https://doi.org/10.1039/c2py20264f
Abstract: Bromide-bearing conjugated fluorene copolymers were prepared by Suzuki coupling polymerization of 2,7-dibromo-9,9-bis(6′-bromohexyl)fluorene and 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-dihexylfluorene. Thiol-functionalized β-cyclodextrin was subsequently grafted to the bromoalkyl side chains of the fluorene copolymers via the thio-bromo 'click' reaction. The resulting fluorene copolymers can self-assemble into fluorescent nanoparticles surrounded by a β-cyclodextrin outer layer in an aqueous medium. Host-guest interactions of the β-cyclodextrin moieties of nanoparticles with the organic guest molecules in the aqueous medium gave rise to variations in the emission intensity of the nanoparticles. The low cytotoxicity of the fluorescent nanoparticles was revealed by incubation with KB cells, a cell line derived from carcinoma of the nasopharynx, in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays in vitro. The biocompatible and fluorescent nanoparticles were further used as effective fluorescence labels for KB cells. © 2012 The Royal Society of Chemistry.
Source Title: Polymer Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/88935
ISSN: 17599954
DOI: 10.1039/c2py20264f
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

15
checked on Feb 27, 2018

WEB OF SCIENCETM
Citations

15
checked on Feb 14, 2018

Page view(s)

39
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.