Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3ob41572d
Title: Fluorescent light-up probe with aggregation-induced emission characteristics for in vivo imaging of cell apoptosis
Authors: Shi, H. 
Zhao, N.
Ding, D. 
Liang, J.
Tang, B.Z.
Liu, B. 
Issue Date: 14-Nov-2013
Citation: Shi, H., Zhao, N., Ding, D., Liang, J., Tang, B.Z., Liu, B. (2013-11-14). Fluorescent light-up probe with aggregation-induced emission characteristics for in vivo imaging of cell apoptosis. Organic and Biomolecular Chemistry 11 (42) : 7289-7296. ScholarBank@NUS Repository. https://doi.org/10.1039/c3ob41572d
Abstract: In this paper, a new live-cell permeable, fluorescent light-up probe comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide and a hydrophobic tetraphenylethene pyridinium unit has been developed for in vivo cell apoptosis imaging and drug screening. The probe shows a specific light-up response to activated caspase-3/7 with a high signal-to-background ratio. The significant fluorescence turn-on response of the probe is due to the aggregation of cleaved hydrophobic residues that populate the radiative decay channels. With good water solubility and biocompatibility, the probe is demonstrated to be a promising candidate for in vivo real time monitoring of caspase activation and in situ screening of apoptosis-inducing drugs. © 2013 The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/88934
ISSN: 14770520
DOI: 10.1039/c3ob41572d
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