Please use this identifier to cite or link to this item: https://doi.org/10.1023/B:BILE.0000023020.12576.1e
Title: Enhanced activity and enantioselectivity of Candida rugosa lipase immobilized on macroporous adsorptive resins for ibuprofen resolution
Authors: Yu, H.
Wu, J.
Chi, B.C. 
Keywords: Candida rugosa
Ibuprofen
Immobilization
Lipase
Macroporous adsorptive resin
Resolution
Issue Date: Apr-2004
Citation: Yu, H., Wu, J., Chi, B.C. (2004-04). Enhanced activity and enantioselectivity of Candida rugosa lipase immobilized on macroporous adsorptive resins for ibuprofen resolution. Biotechnology Letters 26 (8) : 629-633. ScholarBank@NUS Repository. https://doi.org/10.1023/B:BILE.0000023020.12576.1e
Abstract: The lipase from Candida rugosa was immobilized on three commercially available macroporous adsorptive resins for kinetic resolution of ibuprofen. One resin, CRB02, increased the enzyme activity by 50% to 0.027 g g-1 min-1. The deactivation constant (0.19 h-1) of the immobilized enzyme was half of that of the native enzyme and the enantioselectivity (E = 29.2) of the immobilized lipase was 2.2 times as much as that of the native lipase for the kinetic resolution of ibuprofen with 1-propanol in isooctane at 30°C.
Source Title: Biotechnology Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/88844
ISSN: 01415492
DOI: 10.1023/B:BILE.0000023020.12576.1e
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