Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2006.10.009
Title: Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: Effects of phospholipids
Authors: Hadinoto, K.
Phanapavudhikul, P.
Kewu, Z.
Tan, R.B.H. 
Keywords: Dry powder inhaler
Hollow particles
Inhaled drug delivery
Nanoparticulate drugs
Pulmonary delivery
Spray drying
Issue Date: 21-Mar-2007
Citation: Hadinoto, K., Phanapavudhikul, P., Kewu, Z., Tan, R.B.H. (2007-03-21). Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: Effects of phospholipids. International Journal of Pharmaceutics 333 (1-2) : 187-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2006.10.009
Abstract: The present work details the effects of incorporating phospholipids, a major component of lung surfactants, in the formulation of large hollow nanoparticulate aggregates, which are specifically designed to serve as potential carrier particles in inhaled delivery of nanoparticulate drugs. The large hollow aerosol particles (dg ≈ 10 μm), whose shells are composed of nanoparticulate aggregates, are manufactured via the spray drying of nanoparticulate suspensions under a predetermined operating condition. Polyacrylate and silica nanoparticles of various sizes (20-170 nm), without loaded drugs, are employed as the model nanoparticles. The effects of increasing the phospholipids concentration in the presence of the nanoparticles, and vice versa, on the degree of hollowness and morphology of the spray-dried particles are investigated. Varying the phospholipids concentration in the presence of a constant amount of nanoparticles is found to influence the degree of hollowness, without significantly affecting the particle size distribution and respirable fine particle fraction, of the aerosol particles. The effects of increasing the phospholipids concentration on the degree of hollowness of the spray-dried particles are found to depend on the size and chemical nature of the nanoparticles. © 2006 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/88777
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2006.10.009
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