Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2006.07.052
Title: Determination of competitive adsorption isotherm parameters of pindolol enantiomers on α1-acid glycoprotein chiral stationary phase
Authors: Zhang, Y.
Hidajat, K. 
Ray, A.K.
Keywords: α1-Acid glycoprotein
Competitive adsorption isotherm
Enantiomer
Genetic algorithm
Inverse method
Least-square fitting
Pindolol
Issue Date: 27-Oct-2006
Citation: Zhang, Y., Hidajat, K., Ray, A.K. (2006-10-27). Determination of competitive adsorption isotherm parameters of pindolol enantiomers on α1-acid glycoprotein chiral stationary phase. Journal of Chromatography A 1131 (1-2) : 176-184. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2006.07.052
Abstract: In this paper, inverse method (IM) was used to determine the binary competitive adsorption isotherm of pindolol enantiomers by a least-square fitting of the proposed model to the experimentally measured elution curves of racemic pindolol. The isotherm parameters were determined by minimizing the least-square error using an adaptation of genetic algorithm, non-dominated sorting genetic algorithm with jumping genes (NSGA-II-JG). An equilibrium dispersive (ED) model combined with bi-Langmuir isotherm was used in predicting the elution profiles. The determined parameters show good agreement with the experimental profiles at various experimental conditions such as sample volume, concentration and flow rates of the racemic mixture. Robustness and validity of the isotherm parameters were also verified by frontal analyses at various step inputs. Results from both the pulse tests and the frontal analysis indicate that adsorption isotherm derived from the inverse method is quite reliable. This method requires relatively less number of experiments to be performed and therefore, lower experimental costs confirming that inverse method is an attractive alternative approach of experimental technique in determining the competitive adsorption isotherm for binary systems. © 2006 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/88752
ISSN: 00219673
DOI: 10.1016/j.chroma.2006.07.052
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

17
checked on Sep 25, 2018

WEB OF SCIENCETM
Citations

16
checked on Sep 25, 2018

Page view(s)

31
checked on Aug 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.