Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201102353
Title: Conjugated polymer and gold nanoparticle Co-loaded PLGA nanocomposites with eccentric internal nanostructure for dual-modal targeted cellular imaging
Authors: Geng, J.
Li, K.
Pu, K.-Y. 
Ding, D. 
Liu, B. 
Keywords: Au nanoparticles
conjugated polymers
dark-field imaging
dual-modal imaging
fluorescence imaging
Issue Date: 6-Aug-2012
Citation: Geng, J., Li, K., Pu, K.-Y., Ding, D., Liu, B. (2012-08-06). Conjugated polymer and gold nanoparticle Co-loaded PLGA nanocomposites with eccentric internal nanostructure for dual-modal targeted cellular imaging. Small 8 (15) : 2421-2429. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201102353
Abstract: Herein is reported the one-step synthesis of an integrated nanocomposite with eccentrically loaded 5 nm gold nanoparticles (Au NPs) and conjugated polymer of poly[9,9-bis(6'-N,N,N-trimethylammonium)hexyl)fluorenyldivinylene- alt-4,7-(2,1,3,- benzothiadiazole) dibromide] (PFVBT). The nanocomposite is generated with surface-functionalized folic acid groups due to the matrix polymer of PLGA-PEG2000-folate used for encapsulation. The nanocomposite shows far-red fluorescence from PFVBT and scattering signal from Au NPs. Although Au NPs have been widely reported to quench the fluorescence of conjugated polymers, the PFVBT fluorescence is well maintained in the nanocomposite due to the eccentric location of Au NPs. The folic acid groups at the nanocomposite surface favor its cellular uptake by MCF-7 breast cancer cells, which have overexpressed folate receptors on the cell membranes. In conjugation with its low cytotoxicity, the folic-acid-functionalized nanocomposite has been successfully utilized for fluorescence and dark-field dual-modal targeted cellular imaging. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
URI: http://scholarbank.nus.edu.sg/handle/10635/88689
ISSN: 16136810
DOI: 10.1002/smll.201102353
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