Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2013.11.086
Title: Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance
Authors: Zhu, H.
Chen, H.
Zeng, X.
Wang, Z.
Zhang, X.
Wu, Y.
Gao, Y.
Zhang, J.
Liu, K.
Liu, R.
Cai, L.
Mei, L.
Feng, S.-S. 
Keywords: Biodegradable polymers
Cancer nanotechnology
Controlled release
Molecular biomaterial
Nanomedicine
Pharmaceutical nanotechnology
Issue Date: Feb-2014
Citation: Zhu, H., Chen, H., Zeng, X., Wang, Z., Zhang, X., Wu, Y., Gao, Y., Zhang, J., Liu, K., Liu, R., Cai, L., Mei, L., Feng, S.-S. (2014-02). Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance. Biomaterials 35 (7) : 2391-2400. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2013.11.086
Abstract: We report a strategy to make use of poly(lactic-co-glycolic acid) nanoparticle (PLGA NPs) for co-delivery of docetaxel (DTX) as a model anticancer drug together with vitamin E TPGS. The latter plays a dual role as a pore-forming agent in the nanoparticles that may result in smaller particle size, higher drug encapsulation efficiency and faster drug release, and also as a bioactive agent that could inhibit P-glycoprotein to overcome multi-drug resistance of the cancer cells, The DTX-loaded PLGA NPs of 0, 10, 20 and 40% TPGS were prepared by the nanoprecipitation method and then characterized for their size and size distribution, surface morphology, physical status and encapsulation efficiency of the drug in the NPs. All four NPs were found of size ranged 100-120nm and EE ranged 85-95% at drug loading level around 10%. The invitro evaluation showed that the 48h IC50 values of the free DTX and the DTX-loaded PLGA NPs of 0, 10, 20% TPGS were 2.619 and 0.474, 0.040, 0.009μg/mL respectively, which means that the PLGA NPs formulation could be 5.57 fold effective than the free DTX and that the DTX-loaded PLGA NPs of 10 or 20% TPGS further be 11.85 and 52.7 fold effective than the DTX-loaded PLGA NPs of no TPGS (therefore, 66.0 and 284 fold effective than the free DTX). Xenograft tumor model and immunohistological staining analysis further confirmed the advantages of the strategy of co-delivery of anticancer drugs with TPGS by PLGA NPs. © 2013 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/88666
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2013.11.086
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

117
checked on Sep 20, 2018

WEB OF SCIENCETM
Citations

110
checked on Sep 4, 2018

Page view(s)

35
checked on Sep 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.