Please use this identifier to cite or link to this item: https://doi.org/10.1002/macp.200900080
Title: Cationic conjugated polymer/heparin interpolyelectrolyte complexes for heparin quantification
Authors: Shi, J. 
Pu, K.-Y. 
Zhan, R.
Liu, B. 
Keywords: Biosensor
Conjugated polymer
Fluorescence resonance energy transfer (FRET)
Heparin
Quantification
Issue Date: 6-Aug-2009
Source: Shi, J., Pu, K.-Y., Zhan, R., Liu, B. (2009-08-06). Cationic conjugated polymer/heparin interpolyelectrolyte complexes for heparin quantification. Macromolecular Chemistry and Physics 210 (15) : 1195-1200. ScholarBank@NUS Repository. https://doi.org/10.1002/macp.200900080
Abstract: A cationic conjugated polymer (P1) containing 20 mol-% 2,1,3- benzothiadiazole (BT) content is synthesized through a post-polymerization method. With a good water solubility (≈20mg.mL-1), this polymer has shown a low inherent BT emission in aqueous solution. Formation of interpolyelectrolyte complexes between oppositely charged P1 and heparin facilitates energy transfer from the fluorene segments to the BT units within P1, leading to the intensity increase for the orange emission peak at 585nm and the intensity decrease for the blue emission at 412 nm. A practical calibration curve ranging from 0.2 to 76 × 10-6 M is thus obtained by correlating the changes in BT emission with the heparin concentration in buffer. The significant advantage of this heparin macromolecular probe is that the calibration curve could cover the whole range of the therapeutic dosing level of heparin. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Chemistry and Physics
URI: http://scholarbank.nus.edu.sg/handle/10635/88625
ISSN: 10221352
DOI: 10.1002/macp.200900080
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Mar 21, 2018

WEB OF SCIENCETM
Citations

17
checked on Mar 21, 2018

Page view(s)

19
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.