Please use this identifier to cite or link to this item:
https://doi.org/10.1002/smll.201300171
DC Field | Value | |
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dc.title | Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging | |
dc.contributor.author | Ding, D. | |
dc.contributor.author | Liu, J. | |
dc.contributor.author | Feng, G. | |
dc.contributor.author | Li, K. | |
dc.contributor.author | Hu, Y. | |
dc.contributor.author | Liu, B. | |
dc.date.accessioned | 2014-10-09T06:44:05Z | |
dc.date.available | 2014-10-09T06:44:05Z | |
dc.date.issued | 2013-09-23 | |
dc.identifier.citation | Ding, D., Liu, J., Feng, G., Li, K., Hu, Y., Liu, B. (2013-09-23). Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small 9 (18) : 3093-3102. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201300171 | |
dc.identifier.issn | 16136810 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/88595 | |
dc.description.abstract | A highly emissive far-red/near-infrared (FR/NIR) fluorescent conjugated polymer (CP), poly[(9,9-dihexylfluorene)-co-2,1,3-benzothiadiazole-co-4,7- di(thiophen-2-yl)-2,1,3-benzothiadiazole] (PFBTDBT10) is designed and synthesized via Suzuki polymerization. Formulation of PFBTDBT10 using 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000) and DSPE-PEG5000-folate as the encapsulation matrix yielded CP-loaded DSPE-PEG-folic acid nanoparticles (CPDP-FA NPs) with bright FR/NIR fluorescence (27% quantum yield) and a large Stoke's shift of 233 nm in aqueous solution. CPDP-FA NPs show improved thermal/photostabilities and larger Stoke's shifts as compared to commercially available quantum dots (Qdot 655) and organic dyes such as Alexa Fluor 555 and Rhodamine 6G. In vivo studies of CPDP-FA NPs on a hepatoma H22 tumor-bearing mouse model reveal that they could serve as an efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner. Together with the negligible in vivo toxicity, CPDP-FA NPs are promising FR/NIR fluorescent probes for future in vivo applications. Bright far-red/near-infrared conjugated polymer nanoparticles with surface folate ligand and 27% quantum yield in aqueous media are synthesized via a one-step lipid-PEG-folate formulation. The obtained nanoparticles show good thermal/photostabilities and a large Stoke's shift, which compare favorably with commercially available quantum dots (Qdot 655) and organic dyes (Alexa Fluor 555 and Rhodamine 6G), making them a safe and efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/smll.201300171 | |
dc.source | Scopus | |
dc.subject | conjugated polymers | |
dc.subject | fluorescent probes | |
dc.subject | FR/NIR emission | |
dc.subject | in vivo fluorescence imaging | |
dc.subject | in vivo toxicity | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1002/smll.201300171 | |
dc.description.sourcetitle | Small | |
dc.description.volume | 9 | |
dc.description.issue | 18 | |
dc.description.page | 3093-3102 | |
dc.description.coden | SMALB | |
dc.identifier.isiut | 000327821800012 | |
Appears in Collections: | Staff Publications |
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