Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201302114
Title: Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging
Authors: Qin, W.
Li, K.
Feng, G.
Li, M.
Yang, Z.
Liu, B. 
Tang, B.Z.
Keywords: aggregation-induced emission
AIE dots
cell imaging
long-term cell tracing
nucleus imaging
Issue Date: 5-Feb-2014
Citation: Qin, W., Li, K., Feng, G., Li, M., Yang, Z., Liu, B., Tang, B.Z. (2014-02-05). Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Advanced Functional Materials 24 (5) : 635-643. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201302114
Abstract: Efficient long-term cell tracing in a noninvasive and real-time manner is of great importance to understand genesis, development, invasion, and metastasis of cancerous cells. Cell penetrating organic dots with aggregation- induced emission (AIE) characteristics are successfully developed as long-term cell trackers. The AIE dots enjoy the advantages of high emission efficiency, large Stokes shift, good biocompatibility, and high photostability, which ensure their good performance in long-term non-invasive in vitro cell tracing. Moreover, it is the first report that AIE dots exhibit certain permeability to cellular nucleus, making them attractive potential candidates for nucleus imaging. The AIE dots display superior performance compared to their counterparts of inorganic quantum dots, opening a new avenue in the development of fluorescent probes for monitoring biological processes. Encapsulation of orange-red fluorescent luminogens with aggregation-induced emission (AIE) characteristics in biocompatible matrix yields AIE dots with strong emission, large Stokes shift, good biocompatibility, and high photostability. Application of the AIE dots for in vitro cell tracing and nucleus imaging has been demonstrated using MCF-7 breast cancer cells as an example. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Functional Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/88594
ISSN: 1616301X
DOI: 10.1002/adfm.201302114
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