Please use this identifier to cite or link to this item:
|Title:||Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging|
long-term cell tracing
|Source:||Qin, W., Li, K., Feng, G., Li, M., Yang, Z., Liu, B., Tang, B.Z. (2014-02-05). Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Advanced Functional Materials 24 (5) : 635-643. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201302114|
|Abstract:||Efficient long-term cell tracing in a noninvasive and real-time manner is of great importance to understand genesis, development, invasion, and metastasis of cancerous cells. Cell penetrating organic dots with aggregation- induced emission (AIE) characteristics are successfully developed as long-term cell trackers. The AIE dots enjoy the advantages of high emission efficiency, large Stokes shift, good biocompatibility, and high photostability, which ensure their good performance in long-term non-invasive in vitro cell tracing. Moreover, it is the first report that AIE dots exhibit certain permeability to cellular nucleus, making them attractive potential candidates for nucleus imaging. The AIE dots display superior performance compared to their counterparts of inorganic quantum dots, opening a new avenue in the development of fluorescent probes for monitoring biological processes. Encapsulation of orange-red fluorescent luminogens with aggregation-induced emission (AIE) characteristics in biocompatible matrix yields AIE dots with strong emission, large Stokes shift, good biocompatibility, and high photostability. Application of the AIE dots for in vitro cell tracing and nucleus imaging has been demonstrated using MCF-7 breast cancer cells as an example. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Advanced Functional Materials|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 22, 2018
WEB OF SCIENCETM
checked on Jan 22, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.