Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201102191
Title: Biocompatible nanoparticles with aggregation-induced emission characteristics as far-red/near-infrared fluorescent bioprobes for in vitro and in vivo imaging applications
Authors: Qin, W.
Ding, D. 
Liu, J.
Yuan, W.Z.
Hu, Y.
Liu, B. 
Tang, B.Z.
Keywords: aggregation-induced emission
fluorescence bioimaging
nanoparticles
red-light emission
tetraphenylethene
Issue Date: 22-Feb-2012
Citation: Qin, W., Ding, D., Liu, J., Yuan, W.Z., Hu, Y., Liu, B., Tang, B.Z. (2012-02-22). Biocompatible nanoparticles with aggregation-induced emission characteristics as far-red/near-infrared fluorescent bioprobes for in vitro and in vivo imaging applications. Advanced Functional Materials 22 (4) : 771-779. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201102191
Abstract: Light emission of 2-(2,6-bis((E)-4-(diphenylamino)styryl)-4H-pyran-4- ylidene)malononitrile (TPA-DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA-DCM dramatically changes its emission behavior: the resulting fluorogen, 2-(2,6-bis((E)-4-(phenyl(4′- (1,2,2-triphenylvinyl)-[1,1′-biphenyl]-4-yl)amino)styryl) -4H-pyran-4-ylidene)malononitrile (TPE-TPA-DCM), is more emissive in the aggregate state, showing the novel phenomenon of aggregation-induced emission (AIE). Formulation of TPE-TPA-DCM using bovine serum albumin (BSA) as the polymer matrix yields uniformly sized protein nanoparticles (NPs) with high brightness and low cytotoxicity. Applications of the fluorogen-loaded BSA NPs for in vitro and in vivo far-red/near-infrared (FR/NIR) bioimaging are successfully demonstrated using MCF-7 breast-cancer cells and a murine hepatoma-22 (H 22)-tumor-bearing mouse model, respectively. The AIE-active fluorogen-loaded BSA NPs show an excellent cancer cell uptake and a prominent tumor-targeting ability in vivo due to the enhanced permeability and retention effect. Encapsulation of far-red/near-infrared luminogens with aggregation-induced emission (AIE) characteristics in a bovine serum albumin (BSA) matrix yields nanoparticles (NPs) with uniform size, high brightness, and low cytotoxicity. Applications of these AIE-active NPs for in vitro and in vivo fluorescence imaging are demonstrated using MCF-7 breast-cancer cells and a murine hepatic H 22-tumor-bearing mouse model, respectively. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Functional Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/88579
ISSN: 1616301X
DOI: 10.1002/adfm.201102191
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

334
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

320
checked on Jul 9, 2018

Page view(s)

65
checked on Jun 29, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.