Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1747-0285.2009.00860.x
Title: Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates
Authors: Ma, X. 
Woon, R.S.-P.
Ho, P.C.-L. 
Chui, W.-K. 
Keywords: 1,3,5-triazine
Antiproliferative activity
Dihydrofolate reductase inhibitors
Triazaspirodiene
Issue Date: Sep-2009
Source: Ma, X., Woon, R.S.-P., Ho, P.C.-L., Chui, W.-K. (2009-09). Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates. Chemical Biology and Drug Design 74 (3) : 322-326. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1747-0285.2009.00860.x
Abstract: Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian dihydrofolate reductase inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nm) and the other a 6,6-spiro bicyclic system (IC50 = 6.9 nm). They also showed more than 50% antiproliferative activity against the MCF-7 breast cancer cells at 20 μm. This study demonstrated the potential lead of the diamino- triazaspirodienes in anticancer chemotherapeutical agents' discovery. © 2009 John Wiley & Sons A/S.
Source Title: Chemical Biology and Drug Design
URI: http://scholarbank.nus.edu.sg/handle/10635/88547
ISSN: 17470277
DOI: 10.1111/j.1747-0285.2009.00860.x
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