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|Title:||Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates|
|Authors:||Ma, X. |
Dihydrofolate reductase inhibitors
|Source:||Ma, X., Woon, R.S.-P., Ho, P.C.-L., Chui, W.-K. (2009-09). Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates. Chemical Biology and Drug Design 74 (3) : 322-326. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1747-0285.2009.00860.x|
|Abstract:||Two triazaspirodienes, having similar phenoxy propyloxy side chain, were identified as potent mammalian dihydrofolate reductase inhibitors; one having a 6,5-spiro bicyclic ring system (IC50 = 2.3 nm) and the other a 6,6-spiro bicyclic system (IC50 = 6.9 nm). They also showed more than 50% antiproliferative activity against the MCF-7 breast cancer cells at 20 μm. This study demonstrated the potential lead of the diamino- triazaspirodienes in anticancer chemotherapeutical agents' discovery. © 2009 John Wiley & Sons A/S.|
|Source Title:||Chemical Biology and Drug Design|
|Appears in Collections:||Staff Publications|
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