Please use this identifier to cite or link to this item: https://doi.org/10.1089/ten.2007.0063
Title: An integrin-specific collagen-mimetic peptide approach for optimizing Hep3B liver cell adhesion, proliferation, and cellular functions
Authors: Khew, S.T.
Zhu, X.H. 
Tong, Y.W. 
Issue Date: 1-Oct-2007
Citation: Khew, S.T., Zhu, X.H., Tong, Y.W. (2007-10-01). An integrin-specific collagen-mimetic peptide approach for optimizing Hep3B liver cell adhesion, proliferation, and cellular functions. Tissue Engineering 13 (10) : 2451-2463. ScholarBank@NUS Repository. https://doi.org/10.1089/ten.2007.0063
Abstract: This study focused on mimicking collagen structurally and biologically using various peptide sequences toward realizing an artificial collagen-like biomaterial. Collagen-mimetic peptides (CMPs) incorporating integrin-specific glycine-phenylalanine-hydroxyproline-glycine-glutamate-arginine (GFOGER) sequence from residues 502 to 507 of collagen α1(I) were used as a bioadhesive matrix and grafted onto poly(3-hydroxybutyrate-co3- hydroxyvalerate) microspheres to optimize cell adhesion, proliferation, and functions. Cell recognition of these biomolecules appeared to be conformation dependent, with the CMP1 of higher triple helix stability being preferred. Absence of the GFOGER hexapeptide in the CMP1′ and CMP2′ caused an adverse effect on the level of cell adhesion (
Source Title: Tissue Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/88535
ISSN: 10763279
DOI: 10.1089/ten.2007.0063
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

13
checked on Sep 17, 2018

WEB OF SCIENCETM
Citations

19
checked on Sep 5, 2018

Page view(s)

45
checked on Sep 14, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.