Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3nr02390g
Title: A general approach to prepare conjugated polymer dot embedded silica nanoparticles with a SiO2@CP@SiO2 structure for targeted HER2-positive cellular imaging
Authors: Geng, J.
Liu, J.
Liang, J.
Shi, H.
Liu, B. 
Issue Date: 21-Sep-2013
Citation: Geng, J., Liu, J., Liang, J., Shi, H., Liu, B. (2013-09-21). A general approach to prepare conjugated polymer dot embedded silica nanoparticles with a SiO2@CP@SiO2 structure for targeted HER2-positive cellular imaging. Nanoscale 5 (18) : 8593-8601. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr02390g
Abstract: We report on a one-step synthesis of conjugated polymer (CP) embedded silica nanoparticles (NPs) with a SiO2@CP@SiO2 structure by combination of a precipitation method and a modified Stöber approach. Four types of CPs are employed to demonstrate the versatility of the developed strategy, yielding fluorescent silica NPs with emission across the visible spectrum. Field emission transmission electron microscopy investigation reveals that the entanglement between hydrophobic CPs and the aminopropyl groups of 3-aminopropyl triethoxysilane contributes to the successful encapsulation of CPs into a silica matrix. The synthesized NPs exhibit excellent physical stability and good photostability. In addition, they have amine groups on surfaces, which benefit further conjugation for biological applications. Through reaction with a peptide (GGHAHFG) that is specific to the HER2 receptor, the synthesized NPs have been successfully applied for targeted cellular imaging of HER2-overexpressed SKBR-3 breast cancer cells. Along with its high quantum yield and benign biocompatibility, the developed CP embedded silica NPs have great potential for applications in biological imaging. © 2013 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/88445
ISSN: 20403364
DOI: 10.1039/c3nr02390g
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

25
checked on Sep 12, 2018

WEB OF SCIENCETM
Citations

25
checked on Sep 4, 2018

Page view(s)

43
checked on Jul 6, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.