Please use this identifier to cite or link to this item: https://doi.org/10.1260/2040-2295.4.1.23
Title: Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis
Authors: Cheng, W.
Ping, Y.
Zhang, Y. 
Chuang, K.-H.
Liu, Y.
Keywords: Diagnosis
Magnetic resonance imaging (MRI)
Magnetic resonance imaging (MRI) contrast agent
Metabolism
Tumor
Issue Date: Mar-2013
Citation: Cheng, W., Ping, Y., Zhang, Y., Chuang, K.-H., Liu, Y. (2013-03). Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis. Journal of Healthcare Engineering 4 (1) : 23-46. ScholarBank@NUS Repository. https://doi.org/10.1260/2040-2295.4.1.23
Abstract: This review focuses on MRI contrast agents for tumor diagnosis. Several types of low molecular weight Gd3+-based complexes and dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles have been used for clinical tumor diagnosis as longitudinal relaxation time (T1) and transverse relaxation time (T2) MRI contrast agents, respectively. To further improve the sensitivity of MRI, new types of chelates for T1 MRI contrast agents and combination of low molecular weight T1 MRI contrast agents with different types of carriers have been investigated. Different types of materials for forming secure coating layers of SPIO and novel superparamagnetic particles with higher relaxivity values have been explored. Various types of ligands were applied to improve the capability to target tumor for both T1 and T2 contrast agents. Furthermore, MRI contrast agents for detection of tumor metabolism were also pursued.
Source Title: Journal of Healthcare Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/88399
ISSN: 20402295
DOI: 10.1260/2040-2295.4.1.23
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