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Title: Organic Phase Coating of Polymers onto Agarose Microcapsules for Encapsulation of Biomolecules with High Efficiency
Authors: Bai, J.
Mak, W.C.
Chang, X.Y.
Trau, D. 
Keywords: Colloidosome
Polymer capsules
Issue Date: 2009
Citation: Bai, J.,Mak, W.C.,Chang, X.Y.,Trau, D. (2009). Organic Phase Coating of Polymers onto Agarose Microcapsules for Encapsulation of Biomolecules with High Efficiency. IFMBE Proceedings 23 : 821-824. ScholarBank@NUS Repository.
Abstract: The "Matrix-assisted Layer-by-Layer (LbL)" encapsulation technique is one approach to encapsulate biomolecules within hydrogel microcapsules. However, performing "matrix-assisted LbL" encapsulation usually results in low encapsulation efficiency of water soluble biomolecules as these biomolecules leach out into the aqueous phase during the LbL process. To achieve high encapsulation efficiency, the idea of LbL in organic solvents, termed as Reverse-Phase (RP)-LbL, is extended into the "matrix-assisted LbL" encapsulation technique. In this work, agarose microbeads are conferred stability in an organic solvent by fabrication of agarose-based colloidosomes. Next, non-ionized polyelectrolytes (non-ionized poly(allylamine) and non-ionized poly(acrylic acid)) are used to coat the surface of these colloidosomes in organic phase to prevent leakage of preloaded biomolecules from the interior of the colloidosomes. This can allow encapsulation of water soluble biomolecules in agarose microcapsules with high efficiency. © International Federation of Medical and Biological Engineering 2009.
Source Title: IFMBE Proceedings
ISBN: 9783540928409
ISSN: 16800737
DOI: 10.1007/978-3-540-92841-6_202
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