Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.11-7269
Title: Variations in eye volume, surface area, and shape with refractive error in young children by magnetic resonance imaging analysis
Authors: Lim, L.S.
Yang, X. 
Gazzard, G.
Lin, X. 
Sng, C.
Saw, S.-M. 
Qiu, A. 
Issue Date: Nov-2011
Citation: Lim, L.S., Yang, X., Gazzard, G., Lin, X., Sng, C., Saw, S.-M., Qiu, A. (2011-11). Variations in eye volume, surface area, and shape with refractive error in young children by magnetic resonance imaging analysis. Investigative Ophthalmology and Visual Science 52 (12) : 8878-8883. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.11-7269
Abstract: Purpose. To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. Methods. A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS) study underwent MRI using a 3-Tesla whole body scanner with a 32-channel head coil. Eye volume and surface area were measured. Eye shape was assessed qualitatively from the three-dimensional models and quantitatively by measurement of the longitudinal axial length (LAL), horizontal width, and vertical height along the cardinal axes. Results. One hundred thirty-four eyes of 67 subjects (mean age, 77.9 ± 3.9 months) were analyzed. The mean spherical equivalent (SE) refraction was 0.65 ± 0.92 D (range, -2.31 to 4.13 D). More myopic SE was associated with larger surface area (-20.59 [-37.09 to -4.10] mm 2/D; P = 0.01) but not volume. In age-height adjusted models, more myopic SE was associated with longer LAL (-1.94 [-2.47 to -1.41] mm/D; P < 0.001) and greater width (-1.12 [-1.26 to -0.99] mm/D; P < 0.001) but not height (0.64 [-2.55 to 3.82] mm/D; P = 0.70). In nonmyopic subjects, less hyperopic SE was associated with longer AL (-0.40 [-0.71 to -0.10] mm/D; P = 0.01), width (-0.59 [-0.84 to -0.34] mm/D; P < 0.001), and height (-0.40 [-0.64 to -0.17] mm/D; P = 0.001). In three-dimensional models, myopic eyes conformed to an axial elongation model with a prolate profile in the axial plane, whereas nonmyopic eyes showed global expansion. Conclusions. Eye surface area increases with myopia in young children. Eye shape is different in myopia, even in its early stages. Axial globe enlargement occurs in myopic eyes leading to a prolate shape, whereas nonmyopic eyes enlarge globally in length, width, and height. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
URI: http://scholarbank.nus.edu.sg/handle/10635/88214
ISSN: 01460404
DOI: 10.1167/iovs.11-7269
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