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Title: Upconversion nanoparticles for sensitive and in-depth detection of Cu 2+ ions
Authors: Li, C.
Liu, J.
Alonso, S.
Li, F.
Zhang, Y. 
Issue Date: 2012
Citation: Li, C., Liu, J., Alonso, S., Li, F., Zhang, Y. (2012). Upconversion nanoparticles for sensitive and in-depth detection of Cu 2+ ions. Nanoscale 4 (19) : 6065-6071. ScholarBank@NUS Repository.
Abstract: Detection of Cu2+ ions and study of their subcellular distribution in physiological processes are of considerable significance because of their potential environmental and biological applications. Some fluorescence based sensors have been developed for selective detection of Cu2+ ions, based on organic fluorescent probes that specifically bind to Cu 2+ ions. However, these sensors are not suitable for detection in biological samples due to the short penetration depth of UV/visible light used to excite the fluorescent probes. The use of near-infrared (NIR) light can afford penetration depths of an order of magnitude greater than that of visible light, however, a material that can convert NIR light to visible light is required. A facile method has been developed for in-depth detection of Cu 2+ ions based on fluorescence upconversion. A mesoporous silica shell is coated on upconversion nanoparticles (UCNPs) and a Cu2+ ion sensitive fluorescent probe, rhodamine B hydrazide, is incorporated into the mesoporous silica. Upon excitation by a NIR light, the UCNPs emit visible light to excite the Cu2+-sensitive fluorescent probe. Because of the unique optical properties of UCNPs and their ability to convert NIR light to visible light, this is a feasible method for sensitive and in-depth detection of Cu 2+ ions in a complex biological or environmental sample due to the low autofluorescence and the high penetration depth of NIR light. This journal is © 2012 The Royal Society of Chemistry.
Source Title: Nanoscale
ISSN: 20403364
DOI: 10.1039/c2nr31570j
Appears in Collections:Staff Publications

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