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|Title:||Polarization-resolved second-harmonic generation imaging for liver fibrosis assessment without labeling|
|Citation:||Lin, J., Pan, S., Zheng, W., Huang, Z. (2013-10-21). Polarization-resolved second-harmonic generation imaging for liver fibrosis assessment without labeling. Applied Physics Letters 103 (17) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.4826516|
|Abstract:||We apply the polarization-resolved second-harmonic generation (PR-SHG) microscopy to investigate the changes of collagen typings (type I vs type III) and collagen fibril orientations of liver tissue in bile-duct-ligation (BDL) rat models. The PR-SHG results show that the second-order susceptibility tensor ratios (χ31/χ15 and χ33/ χ15) of collagen fibers increase with liver fibrotic progression after BDL surgery, reflecting an increase of the type III collagen component with the severity of liver fibrosis; and the square root of the collagen type III to type I ratio linearly correlates (R2 = 0.98) with histopathological scores. Furthermore, the collagen fibril orientations become more random with liver fibrosis transformation as compared to normal liver tissue. This work demonstrates that PR-SHG microscopy has the potential for label-free diagnosis and characterization of liver fibrosis based on quantitative analysis of collagen typings and fibril orientations. © 2013 AIP Publishing LLC.|
|Source Title:||Applied Physics Letters|
|Appears in Collections:||Staff Publications|
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