Please use this identifier to cite or link to this item: https://doi.org/10.1364/OE.17.002423
Title: Numerical study of effects of light polarization, scatterer sizes and orientations on near-field coherent anti-Stokes Raman scattering microscopy
Authors: Lin, J.
Wang, H.
Zheng, W. 
Lu, F. 
Sheppard, C. 
Huang, Z. 
Issue Date: 16-Feb-2009
Citation: Lin, J., Wang, H., Zheng, W., Lu, F., Sheppard, C., Huang, Z. (2009-02-16). Numerical study of effects of light polarization, scatterer sizes and orientations on near-field coherent anti-Stokes Raman scattering microscopy. Optics Express 17 (4) : 2423-2434. ScholarBank@NUS Repository. https://doi.org/10.1364/OE.17.002423
Abstract: We employ the finite-difference time-domain (FDTD) technique as a numerical approach to studying the effects of polarization, scatterers' sizes and orientations on near-field coherent anti-Stokes Raman scattering (CARS) microscopy imaging. The results show that to acquire better image contrast and larger near-field CARS signals, the scatterers with diameters of less than three-eighths of the pump field wavelength (λp) are preferable to be oriented along the polarization direction of the excitation light fields. It is also found that when the scatterers' sizes are smaller than half a wavelength of the pump field, the perpendicular polarization component of the induced near-field CARS radiations is strictly confined within the regions at the scatterer-water interface or the subsurface of scatterers, yielding a high image contrast (up to 200) with a spatial resolution of λp/16. This study indicates that perpendicular polarization components of near-field CARS microscopy could be used to uncover very fine structures of intra- and/or inter- cellular organelles in cells with nanoscale resolutions. © 2009 Optical Society of America.
Source Title: Optics Express
URI: http://scholarbank.nus.edu.sg/handle/10635/88000
ISSN: 10944087
DOI: 10.1364/OE.17.002423
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