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Title: Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach
Authors: Su, B.
Zhong, L.
Wang, X.-K.
Zhang, J.-M.
Tan, R.S.
Allen, J.C.
Tan, S.K.
Kim, S. 
Leo, H.L. 
Keywords: CFD
Leaflet dynamics
Left ventricular flow
Issue Date: Feb-2014
Citation: Su, B., Zhong, L., Wang, X.-K., Zhang, J.-M., Tan, R.S., Allen, J.C., Tan, S.K., Kim, S., Leo, H.L. (2014-02). Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach. Computer Methods and Programs in Biomedicine 113 (2) : 474-482. ScholarBank@NUS Repository.
Abstract: Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian-Eulerian (ALE) approach was employed to handle the large mesh deformation induced by the beating ventricular wall and moving leaflets. Ventricular wall deformation was predefined based on MRI data, while leaflet dynamics were predicted numerically by fluid-structure interaction (FSI). Comparisons of simulation results with in vitro and in vivo measurements reported in the literature demonstrated that numerical method in combination with MRI was able to predict qualitatively the patient-specific intraventricular flow. To the best of our knowledge, we are the first to simulate patient-specific ventricular flow taking into account both mitral and aortic valves. © 2013 Elsevier Ireland Ltd.
Source Title: Computer Methods and Programs in Biomedicine
ISSN: 01692607
DOI: 10.1016/j.cmpb.2013.11.009
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