Please use this identifier to cite or link to this item:
|Title:||Margination of red blood cells infected by Plasmodium falciparum in a microvessel|
Teck Lim, C.
|Citation:||Imai, Y., Nakaaki, K., Kondo, H., Ishikawa, T., Teck Lim, C., Yamaguchi, T. (2011-05-17). Margination of red blood cells infected by Plasmodium falciparum in a microvessel. Journal of Biomechanics 44 (8) : 1553-1558. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jbiomech.2011.02.084|
|Abstract:||We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a "train". The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel. © 2011 Elsevier Ltd.|
|Source Title:||Journal of Biomechanics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 20, 2018
WEB OF SCIENCETM
checked on Apr 23, 2018
checked on May 18, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.