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|Title:||Margination of red blood cells infected by Plasmodium falciparum in a microvessel|
Teck Lim, C.
|Citation:||Imai, Y., Nakaaki, K., Kondo, H., Ishikawa, T., Teck Lim, C., Yamaguchi, T. (2011-05-17). Margination of red blood cells infected by Plasmodium falciparum in a microvessel. Journal of Biomechanics 44 (8) : 1553-1558. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jbiomech.2011.02.084|
|Abstract:||We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a "train". The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel. © 2011 Elsevier Ltd.|
|Source Title:||Journal of Biomechanics|
|Appears in Collections:||Staff Publications|
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