Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bios.2010.07.030
Title: Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates
Authors: Yuen, C. 
Zheng, W. 
Huang, Z. 
Keywords: Anti-cancer drug
Blood plasma
Cresyl violet
Paclitaxel
Polystyrene bead
Raman spectroscopy
Surface-enhanced Raman scattering
Issue Date: Oct-2010
Citation: Yuen, C., Zheng, W., Huang, Z. (2010-10). Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates. Biosensors and Bioelectronics 26 (2) : 580-584. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bios.2010.07.030
Abstract: We report on a low-level detection of anti-cancer drug (paclitaxel) in blood plasma using microwave-treated gold (Au) film-polystyrene (PS) beads as surface-enhanced Raman scattering (SERS) substrates. SERS spectra of paclitaxel can be acquired within 10s at a concentration of 1×10-8M in blood plasma adsorbed on the modified Au-PS SERS substrates. The concentrations of paclitaxel ranging from 1.0×10-8 to 1.0×10-7M in blood plasma can be well estimated with an accuracy of ~3.8×10-9M using SERS technique. This work shows the promise of applying microwave-modified Au-PS as SERS substrates for rapid and accurate monitoring of the anti-cancer drug in blood plasma for immediate treatment decisions during cancer therapy. © 2010 Elsevier B.V.
Source Title: Biosensors and Bioelectronics
URI: http://scholarbank.nus.edu.sg/handle/10635/87899
ISSN: 09565663
DOI: 10.1016/j.bios.2010.07.030
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