Please use this identifier to cite or link to this item: https://doi.org/10.1021/jp057004g
Title: Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]- poly(ethylene oxide) triblock copolymers in aqueous solution
Authors: Li, X.
Mya, K.Y.
Ni, X.
He, C. 
Leong, K.W.
Li, J. 
Issue Date: 30-Mar-2006
Citation: Li, X., Mya, K.Y., Ni, X., He, C., Leong, K.W., Li, J. (2006-03-30). Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]- poly(ethylene oxide) triblock copolymers in aqueous solution. Journal of Physical Chemistry B 110 (12) : 5920-5926. ScholarBank@NUS Repository. https://doi.org/10.1021/jp057004g
Abstract: The self-aggregation behavior of two amphiphilic poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly-(ethylene oxide) (PEO-PHB-PEO) triblock copolymer samples with nearly identical PHB block lengths but different PEO block lengths, PEO-PHB-PEO(2000-810-2000) and PEO-PHB-PEO(5000-780-5000), was studied with dynamic and static light scattering (DLS and SLS), in combination with fluorescence spectroscopy and transmission electron microscopy (TEM). The formation of polymeric micelles by the two PEO-PHB-PEO triblock copolymers was confirmed with fluorescence technique and TEM. DLS analysis showed that the hydrodynamic radius (R h) of the monodistributed polymeric micelles increased with an increase in PEO block length. The relative thermostability of the triblock copolymer micelles was studied by SLS and DLS at different temperatures. The aggregation number and the ratio of the radius of gyration over hydrodynamic radius were found to be independent of temperature, probably due to the strong hydrophobicity of the PHB block. The combination of DLS and SLS studies indicated that the polymeric micelles were composed of a densely packed core of hydrophobic PHB blocks and a corona shell formed by hydrophilic PEO blocks. The aggregation numbers were found to be ∼53 for PEO-PHB-PEO(2000-810-2000) micelles and ∼37 for PEO-PHB-PEO(5000-780-5000) micelles. The morphology of PEO-PHB-PEO spherical micelles determined by DLS and SLS measurements was further confirmed by TEM. © 2006 American Chemical Society.
Source Title: Journal of Physical Chemistry B
URI: http://scholarbank.nus.edu.sg/handle/10635/87754
ISSN: 15206106
DOI: 10.1021/jp057004g
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

59
checked on Jul 12, 2018

WEB OF SCIENCETM
Citations

58
checked on Jun 5, 2018

Page view(s)

38
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.