Please use this identifier to cite or link to this item: https://doi.org/10.1039/c1py00084e
Title: Clickable poly(ester amine) dendrimer-grafted Fe3O4 nanoparticles prepared via successive Michael addition and alkyne-azide click chemistry
Authors: Li, M.
Xu, L.Q.
Wang, L. 
Wu, Y.P.
Li, J. 
Neoh, K.-G. 
Kang, E.-T. 
Issue Date: Jun-2011
Citation: Li, M., Xu, L.Q., Wang, L., Wu, Y.P., Li, J., Neoh, K.-G., Kang, E.-T. (2011-06). Clickable poly(ester amine) dendrimer-grafted Fe3O4 nanoparticles prepared via successive Michael addition and alkyne-azide click chemistry. Polymer Chemistry 2 (6) : 1312-1321. ScholarBank@NUS Repository. https://doi.org/10.1039/c1py00084e
Abstract: Nanospheres, consisting of a Fe3O4 core, a silica inner shell and dendritic poly(ester amine) (PEA) outer shell, were synthesized via the sol-gel reaction, and successive Michael addition and alkyne-azide click chemistry. The resultant PEA dendrimer-grafted magnetic nanoparticles (Fe 3O4-g-PEA) were characterized by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) spectroscopy, and thermogravimetric (TGA) analysis. Transmission electron microscopy (TEM) images reveal that the Fe3O4-g-PEA magnetic nanoparticles (MNPs) have a uniform size distribution of about 30 nm in diameter. The hydrodynamic size of Fe3O4-g-PEA MNPs changes reversibly with pH of the aqueous medium in the pH range of 3 to 9. The clickable alkyne groups on the surface of Fe3O4-g-PEA MNPs endow these nanoparticles with a functionalizable surface via alkyne-azide click chemistry. Assays with 3T3 fibroblasts and RAW macrophage cells indicate that the Fe3O 4-g-PEA MNPs possess very low cytotoxicity. Hence, the PEA dendrimer-grafted magnetic nanospheres have potential applications as biomedical materials. © 2011 The Royal Society of Chemistry.
Source Title: Polymer Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/87731
ISSN: 17599954
DOI: 10.1039/c1py00084e
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