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|Title:||Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging|
|Authors:||Tan, H. |
|Citation:||Tan, H., Zhang, Y., Wang, M., Zhang, Z., Zhang, X., Yong, A.M., Wong, S.Y., Chang, A.Y.C., Chen, Z.-K., Li, X., Choolani, M., Wang, J. (2012-01). Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging. Biomaterials 33 (1) : 237-246. ScholarBank@NUS Repository.|
|Abstract:||A bioinspired silification approach was successfully used to encapsulate fluorescent conjugated polymers inside silica-shell cross-linked polymeric micelles (CP-SSCL) in the highly benign synthesis environment of room temperature and near-neutral aqueous environment. Four different conjugated polymers were employed to demonstrate the versatility of the bioinspired silification, resulting in the formation of CP-SSCL with different emission wavelengths across the visible spectrum. The CP-SSCL are characterized by a large absorption coefficient and high quantum yield, indicating that they exhibit the required high fluorescence brightness for cellular imaging application. In addition, the CP-SSCL also exhibit a high colloidal stability and low cytotoxicity. The in vitro studies of using MDA-MB-231 breast cancer cells show that the CP-SSCL are successfully uptaken by the cancer cells and located at the cytoplasm of the cells. Furthermore, by conjugating folic acid on their surfaces, the uptake of CP-SSCL by MDA-MB-231 cells was enhanced significantly, suggesting their great potential for targeted imaging and early detection of cancer cells. © 2011 Elsevier Ltd.|
|Appears in Collections:||Staff Publications|
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