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|Title:||Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications|
|Citation:||Maity, D., Chandrasekharan, P., Pradhan, P., Chuang, K.-H., Xue, J.-M., Feng, S.-S., Ding, J. (2011-10-14). Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications. Journal of Materials Chemistry 21 (38) : 14717-14724. ScholarBank@NUS Repository. https://doi.org/10.1039/c1jm11982f|
|Abstract:||In this work, we report a novel method of single step facile synthesis of magnetite nanoclusters via thermal decomposition of iron(iii) acetylacetonate in a liquid mixture of tri(ethylene glycol) (TREG) and triethanolamine (TREA). The optimized ratio of TREG:TREA has been found to be 1:4 (v/v) for the formation of well dispersed MNC-14 magnetite nanoclusters with high Ms values (75 emu g-1) as compared to MNC-10 magnetite nanoparticles (63 emu g-1). The MNC-14 nanoclusters were found to be nontoxic to MCF-7 cells up to an iron concentration of 10 mg ml-1. The MNC-14 nanoclusters yielded high specific absorption rate (SAR) values (∼500 Watt g-1 at 89 kA m-1 AC magnetic field and 240 kHz frequency) and thus qualified for their possible use in magnetic hyperthermia treatment, while MNC-10 nanoparticles possess a much lower SAR value of 135 Watt g -1. In vitro magnetic hyperthermia experiments (using the MNC-14 nanoclusters with the iron concentration of 0.5 mg ml-1) showed about 74% loss in viability of MCF-7 breast cancer cells indicating that they are a very suitable candidate for magnetic hyperthermia treatment of cancer. The r2 and r2* relaxivity values of MNC-14 nanoclusters (294.99 and 450.05 s-1 mM-1) as measured by a 9.4 T MRI scanner were higher than those for the MNC-10 nanoparticles (205.6 and 309.2 s-1 mM-1). The MNC-14 nanoclusters also showed very promising in vivo tumor imaging. Thus, the newly synthesized novel MNC-14 nanoclusters possess great potential in clinical MRI and magnetic hyperthermia applications and may be used simultaneously for cancer diagnosis and therapy. This journal is © The Royal Society of Chemistry.|
|Source Title:||Journal of Materials Chemistry|
|Appears in Collections:||Staff Publications|
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