Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2013.09.034
Title: Membrane assisted micro-solid phase extraction of pharmaceuticals with amino and urea-grafted silica gel
Authors: Lim, T.H.
Hu, L.
Yang, C.
He, C. 
Lee, H.K. 
Keywords: %RSD
μ-SPE
Ami
Amino
APS
APTES
Cbz
Dfn
EF
EME
Enrichment factors
HILIC
HPLC
Ket
LC
LOD
LOQ
LPME
MA
MAME
Membrane microextraction
MS
ODS
PAC
Pharmaceuticals
Rr
SBME
SCR
Sil
Sorbents
SPE
SPME
UPS
UPTMS
Urea
Issue Date: 5-Nov-2013
Citation: Lim, T.H., Hu, L., Yang, C., He, C., Lee, H.K. (2013-11-05). Membrane assisted micro-solid phase extraction of pharmaceuticals with amino and urea-grafted silica gel. Journal of Chromatography A 1316 : 8-14. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2013.09.034
Abstract: Individual polar sorbents with surface-displayed amino groups (APS) and non-nucleophilic urea-groups (UPS), were prepared by chemical modification of granular silica gel with bifunctional silane coupling reagents. In this preliminary study, they were separately employed for micro-solid phase extraction (μ-SPE) of the quarternary salt of Amitriptyline (Ami), Carbamazepine (Cbz), Ketoprofen (Ket) and Diclofenac (Dfn) from aqueous samples in conjunction with high performance liquid chromatography. The resulting enrichment factors for both APS and UPS are comparable and exceeded those of μ-SPE involving commercial C18-silica gel sorbents. The presence of highly polar, but non-basic and non-nucleophilic surfaces on UPS prompted the development of a UPS-based μ-SPE method. Good linear correlation was found over a concentration range of 0-50μgL-1 with limits of detection ranging from 0.66 to 2.36μgL-1). Limits of quantification between 1.61 and 7.88μgL-1 were obtained. HPLC analyses indicated that relative recoveries of 123% for Ami, 65.6% for Cbz, 71.2% for Ket and 66.5% for Dfn were obtained during μ-SPE of spiked (10μgL-1) environmental water samples with percentage relative standard deviations (%RSD) of between 2.1% and 12.6%. © 2013 Elsevier B.V.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/86535
ISSN: 00219673
DOI: 10.1016/j.chroma.2013.09.034
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