Please use this identifier to cite or link to this item:
https://doi.org/10.2217/nnm.10.77
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dc.title | Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications | |
dc.contributor.author | Maity, D. | |
dc.contributor.author | Chandrasekharan, P. | |
dc.contributor.author | Yang, C.-T. | |
dc.contributor.author | Chuang, K.-H. | |
dc.contributor.author | Shuter, B. | |
dc.contributor.author | Xue, J.-M. | |
dc.contributor.author | Ding, J. | |
dc.contributor.author | Feng, S.-S. | |
dc.date.accessioned | 2014-10-07T09:49:20Z | |
dc.date.available | 2014-10-07T09:49:20Z | |
dc.date.issued | 2010-12 | |
dc.identifier.citation | Maity, D., Chandrasekharan, P., Yang, C.-T., Chuang, K.-H., Shuter, B., Xue, J.-M., Ding, J., Feng, S.-S. (2010-12). Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications. Nanomedicine 5 (10) : 1571-1584. ScholarBank@NUS Repository. https://doi.org/10.2217/nnm.10.77 | |
dc.identifier.issn | 17435889 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/86322 | |
dc.description.abstract | Aims: Superparamagnetic magnetite nanoparticles have been under intensive investigation in nanomedicine. However, it is still a challenge to synthesize high-quality water-stable magnetite nanoparticles for better magnetic performance and less side effects in medical MRI and nanothermotherapy. Materials & methods: We successfully synthesized hydrophilic magnetite nanoparticles through thermal decomposition of Fe(acac)3 in triethylene glycol, which were coated with a triethylene glycol layer and thus demonstrated excellent water stability. Results: The optimized deposition temperature has been found to be 250°C (IO-250 NPs). The magnetic and thermal properties as well as the cytotoxicity of IO-250 NPs were investigated. In vitro experiments have demonstrated high cellular uptake and low cytotoxicity. The hyperthermia experiments showed effectiveness in temperature rise and cancer cell death. IO-250 NPs showed promising MRI with relaxivity r2* as high as 617.5 s-1 mM-1 Fe. In vivo MRI showed excellent tumor imaging. Conclusion: The IO-250 NPs have great potential to be applied for clinical MRI and magnetic thermotherapy. © 2010 Future Medicine Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2217/nnm.10.77 | |
dc.source | Scopus | |
dc.subject | cancer diagnosis and treatment | |
dc.subject | cellular and molecular imaging | |
dc.subject | magnetic nanocrystals | |
dc.subject | magnetic nanothermotherapy | |
dc.subject | magnetite nanoparticles | |
dc.subject | superparamagnetic iron oxides | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.contributor.department | MATERIALS SCIENCE AND ENGINEERING | |
dc.description.doi | 10.2217/nnm.10.77 | |
dc.description.sourcetitle | Nanomedicine | |
dc.description.volume | 5 | |
dc.description.issue | 10 | |
dc.description.page | 1571-1584 | |
dc.identifier.isiut | 000286541700012 | |
Appears in Collections: | Staff Publications |
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