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|Title:||Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications|
|Keywords:||cancer diagnosis and treatment|
cellular and molecular imaging
superparamagnetic iron oxides
|Citation:||Maity, D., Chandrasekharan, P., Yang, C.-T., Chuang, K.-H., Shuter, B., Xue, J.-M., Ding, J., Feng, S.-S. (2010-12). Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications. Nanomedicine 5 (10) : 1571-1584. ScholarBank@NUS Repository. https://doi.org/10.2217/nnm.10.77|
|Abstract:||Aims: Superparamagnetic magnetite nanoparticles have been under intensive investigation in nanomedicine. However, it is still a challenge to synthesize high-quality water-stable magnetite nanoparticles for better magnetic performance and less side effects in medical MRI and nanothermotherapy. Materials & methods: We successfully synthesized hydrophilic magnetite nanoparticles through thermal decomposition of Fe(acac)3 in triethylene glycol, which were coated with a triethylene glycol layer and thus demonstrated excellent water stability. Results: The optimized deposition temperature has been found to be 250°C (IO-250 NPs). The magnetic and thermal properties as well as the cytotoxicity of IO-250 NPs were investigated. In vitro experiments have demonstrated high cellular uptake and low cytotoxicity. The hyperthermia experiments showed effectiveness in temperature rise and cancer cell death. IO-250 NPs showed promising MRI with relaxivity r2* as high as 617.5 s-1 mM-1 Fe. In vivo MRI showed excellent tumor imaging. Conclusion: The IO-250 NPs have great potential to be applied for clinical MRI and magnetic thermotherapy. © 2010 Future Medicine Ltd.|
|Appears in Collections:||Staff Publications|
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