Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2011.12.025
Title: The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application
Authors: Zhang, Z.-Y. 
Teoh, S.-H. 
Hui, J.H.P.
Fisk, N.M.
Choolani, M.
Chan, J.K.Y.
Keywords: Bioreactor
Bone tissue engineering
Mesenchcymal stem cells
Scaffold
Issue Date: Mar-2012
Citation: Zhang, Z.-Y., Teoh, S.-H., Hui, J.H.P., Fisk, N.M., Choolani, M., Chan, J.K.Y. (2012-03). The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application. Biomaterials 33 (9) : 2656-2672. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2011.12.025
Abstract: Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications. In this review, we first highlight recent progress in the understanding of MSC biology, their invivo niche, multi-faceted contribution to fracture healing and bone re-modelling, and their role in BTE. A literature review from clinicaltrials.gov and Pubmed on clinical usage of MSC for both orthopedic and non-orthopedic indications suggests that translational use of MSC for BTE indications is likely to bear fruit in the ensuing decade. Last, we disscuss the profound influence of ontological and antomical origins of MSC on their proliferation and osteogenesis and demonstrated human fetal MSC (hfMSC) as a superior cellular candidate for off-the-shelf BTE applications. This relates to their superior proliferation capacity, more robust osteogenic potential and lower immunogenecity, as compared to MSC from perinatal and postnatal sources. Furthermore, we discuss our experience in developing a hfMSC based BTE strategy with the integrated use of bioreactor-based dynamic priming within macroporous scaffolds, now ready for evaluation in clinical trials. In conclusion, hfMSC is likely the most promising cell source for allogeneic based BTE application, with proven advantages compared to other MSC based ones. © 2011 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/86157
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2011.12.025
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

75
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

70
checked on Jun 20, 2018

Page view(s)

53
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.