Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-540-92841-6_314
Title: A Biofunctional Fibrous Scaffold for the Encapsulation of Human Mesenchymal Stem Cells and its Effects on Stem Cell Differentiation
Authors: Yow, S.Z.
Quek, C.H.
Yim, E.K.F. 
Leong, K.W. 
Lim, C.T. 
Keywords: Biomimetic scaffold
Cell encapsulation
Collagen
Polyelectrolyte complex fibers
Stem cell
Issue Date: 2009
Source: Yow, S.Z.,Quek, C.H.,Yim, E.K.F.,Leong, K.W.,Lim, C.T. (2009). A Biofunctional Fibrous Scaffold for the Encapsulation of Human Mesenchymal Stem Cells and its Effects on Stem Cell Differentiation. IFMBE Proceedings 23 : 1279-1281. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-540-92841-6_314
Abstract: We report a collagen based fibrous scaffold for the encapsulation and seeding of human mesenchymal stem cells. The scaffold was fabricated through interfacial polyelectrolyte complexation (IPC) of an anionic synthetic terpolymer and a cationic methylated collagen in aqueous conditions. The collagen in the fibers was labeled with quantum dots and was found to be evenly distributed in each fiber strand. Encapsulating human mesenchymal stem cells (hMSCs) into these collagen based fibers and maintaining the viability are steps towards the creation of a biofunctionalised scaffold and the existing problems of the lack of cell infiltration in scaffolds and effective nutrient/waste exchange can be overcome. This cell encapsulation in scaffolds technique is simple and least toxic compared to existing fabrication techniques. hMSCs were seeded onto the fibrous scaffold and compared with hMSCs encapsulated within the scaffold. The cytoskeletal organization of seeded hMSCs and encapsulated hMSCs were different and the results were correlated to the gene expressions of both samples. © International Federation of Medical and Biological Engineering 2009.
Source Title: IFMBE Proceedings
URI: http://scholarbank.nus.edu.sg/handle/10635/85849
ISBN: 9783540928409
ISSN: 16800737
DOI: 10.1007/978-3-540-92841-6_314
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

2
checked on Feb 13, 2018

Page view(s)

57
checked on Feb 17, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.