Please use this identifier to cite or link to this item:
|Title:||Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells|
Hematopoietic stem cells
Stem cell therapy
|Citation:||Chua, K.-N., Chai, C., Lee, P.-C., Tang, Y.-N., Ramakrishna, S., Leong, K.W., Mao, H.-Q. (2006-12). Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells. Biomaterials 27 (36) : 6043-6051. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.06.017|
|Abstract:||Interaction between hematopoietic stem/progenitor cells (HSPCs) and their extra cellular matrix components is an integral part of the signaling control for HSPC survival, proliferation and differentiation. We hypothesized that both substrate topographical cues and biochemical cues could act synergistically with cytokine supplementation to improve ex vivo expansion of HSPCs. In this study, we compared the ex vivo expansion of human umbilical cord blood CD34+ cells on unmodified, hydroxylated, carboxylated and aminated nanofibers and films. Results from 10-day expansion cultures showed that aminated nanofiber mesh and film were most efficient in supporting the expansion of the CD34+CD45+ cells (195-fold and 178-fold, respectively), as compared to tissue culture polystyrene (50-fold, p|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 13, 2018
WEB OF SCIENCETM
checked on Jun 12, 2018
checked on Jun 29, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.