Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201200435
Title: Mimicking nanofibrous hybrid bone substitute for mesenchymal stem cells differentiation into osteogenesis
Authors: Gandhimathi, C.
Venugopal, J. 
Ravichandran, R.
Sundarrajan, S. 
Suganya, S.
Ramakrishna, S. 
Keywords: Bone tissue engineering
Nanofibrous scaffolds
Nanohydroxyapatite
Osteogenic differentiation
Polyaspartic acid
Issue Date: Jun-2013
Source: Gandhimathi, C., Venugopal, J., Ravichandran, R., Sundarrajan, S., Suganya, S., Ramakrishna, S. (2013-06). Mimicking nanofibrous hybrid bone substitute for mesenchymal stem cells differentiation into osteogenesis. Macromolecular Bioscience 13 (6) : 696-706. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201200435
Abstract: Mimicking hybrid extracellular matrix is one of the main challenges for bone tissue engineering (BTE). Biocompatible polycaprolactone/poly(α,β)-DL-aspartic acid/collagen nanofibrous scaffolds were fabricated by electrospinning and nanohydroxyapatite (n-HA) was deposited by calcium phosphate dipping method for BTE. Human mesenchymal stem cells (hMSCs) were cultured on these hybrid scaffolds to investigate the cell proliferation, osteogenic differentiation by alkaline phosphatase activity, mineralization, double immunofluorescent staining using CD90 and expression of osteocalcin. The present study indicated that the PCL/PAA/collagen/n-HA scaffolds promoted greater osteogenic differentiation of hMSCs, proving to be a potential hybrid scaffolds for BTE. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
URI: http://scholarbank.nus.edu.sg/handle/10635/85419
ISSN: 16165187
DOI: 10.1002/mabi.201200435
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

26
checked on Jan 15, 2018

WEB OF SCIENCETM
Citations

24
checked on Jan 15, 2018

Page view(s)

27
checked on Jan 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.