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Title: Development of perforated microthin poly(E-caprolactone) films as matrices for membrane tissue engineering
Authors: Htay, A.S.
Teoh, S.H. 
Hutmacher, D.W. 
Keywords: Accelerated degradation
Biaxial stretching
Perforated film
Sodium hydroxide
Tissue engineering
Water vapour transmission
Issue Date: 2004
Citation: Htay, A.S., Teoh, S.H., Hutmacher, D.W. (2004). Development of perforated microthin poly(E-caprolactone) films as matrices for membrane tissue engineering. Journal of Biomaterials Science, Polymer Edition 15 (5) : 683-700. ScholarBank@NUS Repository.
Abstract: The design and fabrication of thin films based on bioresorbable polymers such as poly(E-caprolactone) (PCL) has been the focus of a part of current biomedical research, especially as matrices for membrane tissue engineering. We have successfully developed perforated microthin PCL membrane for this purpose. Two critical issues are the control of moisture permeability and understanding the degradation of PCL microthin film. In order to increase the moisture permeability, PCL films were biaxially stretched to a thickness of 10 ± 3 μm and perforated with uniform array of holes (180-275 μm) using a Sony Robotic system. After perforation, the water vapour transmission rate was increased by 50% to a value of 47.6 ± 2.7 g/h per m2. Accelerated hydrolytic degradations were performed in 5 M NaOH. The degraded samples were characterised for changes in weight, surface morphology, mechanical properties, crystallinity and molecular weight. Hydrolytic degradation commenced with random chain scission of backbone ester bonds on the film surface and followed by loss of material due to surface erosion. In general, the perforated films degraded faster than the unperforated microthin films. Scanning electron microscopic images showed that surface erosion led to extensive formation of micropores, microcracks and increased in surface roughness. © VSP 2004.
Source Title: Journal of Biomaterials Science, Polymer Edition
ISSN: 09205063
DOI: 10.1163/156856204323046933
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