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|Title:||Nonlinear control of synaptic plasticity model for constraining bursting activity in epileptic seizures|
Al Mamun, A.
Synaptic plasticity model
|Source:||Pan, Y.,Ge, S.S.,Al Mamun, A. (2007). Nonlinear control of synaptic plasticity model for constraining bursting activity in epileptic seizures. Proceedings of the American Control Conference : 2012-2017. ScholarBank@NUS Repository. https://doi.org/10.1109/ACC.2007.4282612|
|Abstract:||In this paper, we address the problem of controlling the synaptic plasticity to constraint bursting activity in epileptic seizures by a direct drug injection. With a good understanding of dynamical changes in seizures onset and the mechanisms that cause these changes, we design a control based on a model of interaction between synaptic strength and the intracellular calcium concentration [Ca2+ ]i. By exploring the dynamic properties of the system, the original system is first regrouped into two subsystems, the first one is a self-stable system; and the second one is a second order system in strict feedback form. Then, nonlinear control for the second subsystem is presented through backstepping design. The closed-loop system is shown to be globally stable. Simulation studies are conducted to show the effectiveness of the control for stopping the bursting activity in brain with epilepsy. © 2007 IEEE.|
|Source Title:||Proceedings of the American Control Conference|
|Appears in Collections:||Staff Publications|
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