Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/80267
Title: THE ROLE OF WNTS IN ADULT MURINE HEMATOPOIESIS AND INTESTINAL HOMEOSTASIS
Authors: ZAHRA KABIRI
Keywords: Porcn, Wnt, Hematopoiesis, Intestine, Homeostasis
Issue Date: 9-Jun-2014
Citation: ZAHRA KABIRI (2014-06-09). THE ROLE OF WNTS IN ADULT MURINE HEMATOPOIESIS AND INTESTINAL HOMEOSTASIS. ScholarBank@NUS Repository.
Abstract: WNT PROTEINS BELONG TO A FAMILY OF SECRETED AUTOCRINE AND PARACRINE HORMONES THAT REGULATE CELL PROLIFERATION AND MIGRATION, EMBRYONIC DEVELOPMENT, AND ADULT TISSUE HOMEOSTASIS. ABERRANT REGULATION OF WNT PATHWAYS IS INVOLVED IN VARIOUS DISEASES. THUS, INHIBITION OF WNT PATHWAYS WILL PROBABLY BENEFIT PATIENTS WITH HIGH WNT DISEASE SUCH AS CANCER AND FIBROSIS. HOWEVER, IF WNT PATHWAYS ARE REQUIRED FOR SELF-RENEWAL OF ADULT STEM CELLS, INHIBITION OF WNTS MIGHT HAVE ADVERSE EFFECTS ON NORMAL TISSUE HOMEOSTASIS. TO ADDRESS THE ROLE AND SOURCE OF WNT PATHWAYS IN ADULT TISSUE HOMEOSTASIS, WE USED PHARMACOLOGICAL AND GENETIC APPROACHES TO INHIBIT WNT SECRETIONS IN MICE BY TARGETING PORCN, AN ENZYME REQUIRED FOR SECRETION AND NORMAL ACTIVITY OF ALL WNTS. GENETIC ABLATION OF PORCN SHOWED THE ROLE OF INTESTINAL EPITHELIAL WNTS IN EX VIVO CULTURE. UNEXPECTEDLY, MICE LACKING EPITHELIAL WNT ACTIVITY (VILLIN-CRE/PORCNDEL MICE) HAD NORMAL INTESTINAL PROLIFERATION AND DIFFERENTIATION, AS WELL AS SUCC
URI: http://scholarbank.nus.edu.sg/handle/10635/80267
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Kabiri Zahra.pdf12.29 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

131
checked on Nov 9, 2018

Download(s)

23
checked on Nov 9, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.