Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/80222
Title: Applications of Oligopeptides and Liquid Crystals for Chemical Sensing
Authors: DING XIAOKANG
Keywords: liquid crystal, surface plasmon resonance (SPR), biosensors, human chorionic gonadotropin (hCG), enzymatic silver deposition, neonicotinoids
Issue Date: 31-Jul-2013
Citation: DING XIAOKANG (2013-07-31). Applications of Oligopeptides and Liquid Crystals for Chemical Sensing. ScholarBank@NUS Repository.
Abstract: Detecting small molecules and proteins is important in medical diagnosis, environmental monitoring and food safety. In Chapter 3, we developed an LC-based sensor to detect butylamine. This LC sensor doped with lauric aldehyde shows fast and distinct bright-to-dark optical response to butylamine. However, this sensor can also respond to other amines such as diisopropylamine and octylamine. To achieve better specificity, in Chapter 4 and 5, we identified oligopeptides that specifically bind to thiacloprid, imidacloprid, and glyphosate by using phage display screening, and we integrated the oligopeptides in SPR biosensors for detecting such molecules. In Chapter 6, we combined LC and oligopeptide to develop an LC sensor for detecting hCG, and in Chapter 7, we tried to amplify the LC signal by using enzymatic silver deposition. The new generation of LC-based optical sensor has potential to be developed as portable sensing devices or diagnostic kits in the future.
URI: http://scholarbank.nus.edu.sg/handle/10635/80222
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
DingXK.pdf5.45 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

138
checked on Oct 12, 2018

Download(s)

257
checked on Oct 12, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.