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Title: Development of Mediatorless Glucose Sensing Strategies for Blood Glucose Monitoring in Diabetes
Authors: ZHENG DAN
Keywords: Electrochemistry, Mediatorless, Blood glucose monitoring, Glucose biosensor, Interference-free, Diabetes management
Issue Date: 21-Jan-2014
Source: ZHENG DAN (2014-01-21). Development of Mediatorless Glucose Sensing Strategies for Blood Glucose Monitoring in Diabetes. ScholarBank@NUS Repository.
Abstract: Based on the functionalization of 3-aminopropyltriethoxysilane, glucose oxidase, carbon nanotubes or graphene on the surface of glassy carbon electrode, this study proposed several convenient and advanced mediatorless electrochemical sensing strategies for blood glucose monitoring in diabetic management. The concentration effect of 3-aminopropyltriethoxysilane on the electrocatalysis of glucose biosensing formats, the effect of interferents and bio-fouling on glucose detection, production reproducibility, biosensor stability and other sensor parameters were investigated. The results show that all glucose biosensors could precisely detect glucose in the diabetic pathophysiological range of 1-30 mM and were free from interference. Additionally, some of the strategies were proved to be suitable for continuous glucose monitoring owing to their high stability and excellent anti-biofouling capability. This study may be practically beneficial to the fabrication of mediatorless biosensors for determining analytes of interest. Moreover, the systematic investigation of sensor performance should provide valuable guidelines for the development of non-invasive glucose sensor.
Appears in Collections:Ph.D Theses (Open)

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