Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/80184
Title: ENDOMETRIAL STROMAL CELL DYSREGULATION IN ENDOMETRIOSIS
Authors: TAN CHIN WEN
Keywords: Endometriosis, Endometrial Stromal Cells, Hypoxia, CD26/DPPIV, Glucosylceramide
Issue Date: 17-Jan-2014
Source: TAN CHIN WEN (2014-01-17). ENDOMETRIAL STROMAL CELL DYSREGULATION IN ENDOMETRIOSIS. ScholarBank@NUS Repository.
Abstract: The aetiological origin of endometriosis has remained controversial, with effects of local cellular environment around endometrial cells on lesion initiation being an active area of investigation. Endometrial stromal cells (ESCs) are more migratory under normoxia in women with endometriosis as compared with those from control subjects, but little is known about the relationship between physiological oxygen tension (hypoxia) and cellular migration in the lesion development. Differed by a group, glucosylceramide (GlcCer) and ceramide (Cer) confer distinctly different glycosyl functions in controlling cell growth. Nevertheless, the role of these sphingolipids remains unknown in endometriosis to date despite their elevated levels found in the diseased serum and peritoneal fluid. My findings suggest that both CD26/DPPIV downregulation and increased GlcCer levels are able to promote ESCs migration or/and proliferation in endometriosis especially under hypoxia. This finding may contribute to the development of novel means to diagnose or mitigate the lesion progression in endometriosis.
URI: http://scholarbank.nus.edu.sg/handle/10635/80184
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