Please use this identifier to cite or link to this item:
https://doi.org/10.1111/eos.12091
DC Field | Value | |
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dc.title | Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin | |
dc.contributor.author | Vinoth, J.K. | |
dc.contributor.author | Patel, K.J. | |
dc.contributor.author | Lih, W.-S. | |
dc.contributor.author | Seow, Y.-S. | |
dc.contributor.author | Cao, T. | |
dc.contributor.author | Meikle, M.C. | |
dc.date.accessioned | 2014-09-18T09:22:13Z | |
dc.date.available | 2014-09-18T09:22:13Z | |
dc.date.issued | 2013-12 | |
dc.identifier.citation | Vinoth, J.K., Patel, K.J., Lih, W.-S., Seow, Y.-S., Cao, T., Meikle, M.C. (2013-12). Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin. European Journal of Oral Sciences 121 (6) : 517-524. ScholarBank@NUS Repository. https://doi.org/10.1111/eos.12091 | |
dc.identifier.issn | 09098836 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/79869 | |
dc.description.abstract | To understand, in greater detail, the molecular mechanisms regulating the complex relationship between mechanical strain and alveolar bone metabolism during orthodontic treatment, passive cross-arch palatal springs were bonded to the maxillary molars of 6-wk-old rats, which were killed after 4 and 8 d. Outcome measures included serum assays for markers of bone formation and resorption and for the multifunctional hormone leptin, and histomorphometry of the inter-radicular bone. The concentration of the bone-formation marker alkaline phosphatase (ALP) was significantly reduced at both time points in the appliance group, accompanied by a 50% reduction in inter-radicular bone volume; however, osteocalcin (bone Gla protein) levels remained unaffected. Bone collagen deoxypyridinoline (DPD) crosslinks increased 2.3-fold at 4 d only, indicating a transient increase in bone resorption; in contrast, the level of the osteoclast-specific marker, tartrate-resistant acid phosphatase 5b (TRACP 5b), was unchanged. Leptin levels closely paralleled ALP reductions at both time points, suggesting an important role in the mechanostat negative-feedback loop required to normalize bone mass. These data suggest that an orthodontic appliance, in addition to remodeling the periodontal ligament (PDL)-bone interface, may exert unexpected side-effects on the tooth-supporting alveolar bone, and highlights the importance of recognizing that bone strains can have negative, as well as positive, effects on bone mass. © 2013 Eur J Oral Sci. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/eos.12091 | |
dc.source | Scopus | |
dc.subject | Alkaline phosphatase | |
dc.subject | Deoxypyridinoline crosslinks | |
dc.subject | Leptin | |
dc.subject | Osteopenia | |
dc.subject | Tartrate-resistant acid phosphatase 5b | |
dc.type | Article | |
dc.contributor.department | DENTISTRY | |
dc.description.doi | 10.1111/eos.12091 | |
dc.description.sourcetitle | European Journal of Oral Sciences | |
dc.description.volume | 121 | |
dc.description.issue | 6 | |
dc.description.page | 517-524 | |
dc.identifier.isiut | 000330973300002 | |
Appears in Collections: | Staff Publications |
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