Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/79732
Title: SYNTHESIS OF SMALL MOLECULES FOR STEM CELL DIFFERENTIATION AND CELLULAR REPROGRAMMING
Authors: LOW JOO LENG
Keywords: Small molecules, inhibitors, stem cells, differentiation, reprogramming, target identification
Issue Date: 9-May-2014
Citation: LOW JOO LENG (2014-05-09). SYNTHESIS OF SMALL MOLECULES FOR STEM CELL DIFFERENTIATION AND CELLULAR REPROGRAMMING. ScholarBank@NUS Repository.
Abstract: STEM CELLS ARE UNSPECIALIZED CELLS WITH THE CAPABILITY FOR SELF-RENEWAL OR DIFFERENTIATION INTO SPECIALIZED CELLS UPON INDUCTION BY APPROPRIATE SIGNALS. PARTICULARLY, THE ABILITY OF STEM CELLS TO DIFFERENTIATE INTO CARDIOMYOCYTES HAS ATTRACTED OUR INTEREST AS SUCH CELLS CAN BE APPLIED IN DRUG DISCOVERY PROGRAMS AS WELL IN REGENERATIVE THERAPY FOR HEART FAILURE PATIENTS. IN THIS PROJECT WE DESIGNED AND SYNTHESIZED A LIBRARY OF SMALL MOLECULES AND INVESTIGATED THEIR CARDIOMYOGENIC ACTIVITIES WITH THE AIM OF IMPROVING THE YIELD OF CARDIOMYOCYTES OBTAINED IN DIFFERENTIATION PROTOCOLS. THESE SMALL MOLECULES WERE ALSO USED AS PROBES TO INVESTIGATE THE MECHANISMS INVOLVED IN CARDIOMYOCYTE DIFFERENTIATION. LASTLY WE INVESTIGATED THE USE OF SMALL MOLECULES FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS (IPSCS). THE GENERATION OF PATIENT-SPECIFIC IPSCS AND CONSEQUENTLY THE DIFFERENTIATION OF THESE IPSCS INTO CARDIOMYOCYTES WOULD AVOID THE PROBLEMS OF ETHICS AND TISSUE REJECTION ASSOCIATED
URI: http://scholarbank.nus.edu.sg/handle/10635/79732
Appears in Collections:Ph.D Theses (Open)

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