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Title: Characterizing Iris Surface Features and their Association with Angle Closure Related Traits in Asian Eyes
Keywords: Iris, Angle Closure, Glaucoma, Asian, Primary Angle Closure Disease, Iris Surface Features
Issue Date: 23-Apr-2014
Citation: ELIZABETH SIDHARTHA (2014-04-23). Characterizing Iris Surface Features and their Association with Angle Closure Related Traits in Asian Eyes. ScholarBank@NUS Repository.
Abstract: The iris plays an important role in angle closure disease. We propose that iris surface features such as iris crypts, contraction furrows and iris color are novel biomarkers for angle closure. Standardized slit lamp iris photographs were obtained from 600 subjects from the Singapore Epidemiology of Eye Diseases (SEED) study. We developed a grading system assessing iris crypts (by number and size), furrows (by number and circumferential extent), and color (higher grade denoting darker iris). We showed that these features correlate well with iris thickness and angle width measured by Anterior Segment Optical Coherence Tomography (AS-OCT). Eyes with more iris crypts had thinner iris and wider angle; irises with more extensive furrows are thicker peripherally; and darker eyes had thicker peripheral iris and narrower angle. These findings may provide another means to assess angle closure risk based on iris features.
Appears in Collections:Master's Theses (Open)

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